Green Synthesis of Novel 1, 8-Naphthyridinyl Heterocycles

This book delves into the synthesis of 1,8-naphthyridines, a class of nitrogen heterocycles known for their significant biological activities. It covers the methods of organic synthesis involved in the creation of these compounds, with a particular focus on two major approaches: cyclization into pyridine rings (Type-I) and cyclization with 3-substituted 2-aminopyridines (Type-II). The book elaborates on classic methods such as the Ethoxymethylenemalonic Ester (EMME) method, Conrad-Limpach and Knorr methods, and Chichibabin's synthesis, providing detailed mechanisms and illustrations. It is an invaluable resource for researchers and students in the fields of organic chemistry and pharmaceutical science.

This book explores the synthesis of 1,8-naphthyridines, highlighting their importance as bioactive agents in pharmaceutical chemistry. It covers the two primary types of synthesis: Type-I, which involves cyclization into a pyridine ring, and Type-II, which uses 3-substituted 2-aminopyridines for cyclization. The book provides in-depth discussions on key methods such as the Ethoxymethylenemalonic Ester method, Conrad-Limpach and Knorr reactions, and Chichibabin's synthesis, along with detailed reaction mechanisms and synthetic pathways. Offering insights into the molecular complexity of organic synthesis, it is a crucial reference for students and professionals interested in organic synthesis and drug development.

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