Description
This book delves into the synthesis of 1,8-naphthyridines, a class of nitrogen heterocycles known for their significant biological activities. It covers the methods of organic synthesis involved in the creation of these compounds, with a particular focus on two major approaches: cyclization into pyridine rings (Type-I) and cyclization with 3-substituted 2-aminopyridines (Type-II). The book elaborates on classic methods such as the Ethoxymethylenemalonic Ester (EMME) method, Conrad-Limpach and Knorr methods, and Chichibabin's synthesis, providing detailed mechanisms and illustrations. It is an invaluable resource for researchers and students in the fields of organic chemistry and pharmaceutical science.
