Synthesis of Some New Heterocycles Containing 1,2,3-Triazole Pharmacophore and their Anticancer Evaluation

This book outlines the synthesis and anticancer evaluation of novel heterocyclic compounds incorporating the 1,2,3-triazole pharmacophore. The introductory chapter provides an overview of cancer biology and the therapeutic potential of triazole-based compounds, alongside key synthetic methodologies. Chapter two highlights the development of Clioquinol-fused 1,2,3-triazoles and their cytotoxic activity, including binding interactions with tubulin protein. The third chapter focuses on the synthesis of indole–1,2,4-oxadiazole–1,2,3-triazole hybrids and their inhibition of the epidermal growth factor receptor (EGFR). The final chapter presents isoindole-linked 1,2,3-triazoles and their anti-proliferative effects, supported by molecular docking with EGFR. The findings demonstrate the structural diversity and therapeutic promise of triazole-based heterocycles in anticancer drug discovery.

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