Periodontal diseases, affecting 51% of India's population, present a significant public health challenge, with 26.2% experiencing mild to moderate periodontitis and 19% facing severe cases. If left untreated, these conditions can lead to tissue damage and tooth loss, necessitating advanced therapeutic approaches. Unlike skin wounds, the oral environment demands specialized regenerative strategies for effective healing. Conventional treatments primarily focus on managing infection and inflammation but fall short in promoting tissue regeneration. Recent advancements in periodontal regenerative therapies, including guided tissue regeneration, growth factor applications, and bioengineering, offer promising solutions for restoring periodontal structures. This book provides a comprehensive overview of cutting-edge techniques in tissue engineering for periodontal regeneration, highlighting innovations in biomaterials, drug delivery systems, and bio-inspired scaffolds. It also addresses key challenges and opportunities for developing transformative therapies in periodontal care.