Oral cancer is the sixth most common cancer worldwide with the age standardized incidence rate of 3.9 per 100,000 populations worldwide. This dreaded malignancy stems as the major health concern due to rising trends in younger population. The Indian subcontinent accounts for one-third of the world burden of this malignancy. It is the most common form of cancer and accounts for increasing number of cancer related deaths among men in India. Many patients who are successfully treated for oral cancer have to cope with the devastating consequences of their treatment. These may affect the patient’s appearance and function, e.g. eating, drinking, swallowing and speaking. These residual defects may lead to other problems such as depression and nutritional deficiency.This text book delivers indispensable content to students, residents and clinicians from many different health disciplines seeking to understand and advance their knowledge about the different aspect of oral cancer and the role of tumor markers in the early diagnosis and management of oral cancer.