Over 90% of oral cancers are squamous cell carcinomas. The WHO grading system, based on cellular differentiation, is used in routine pathology reporting and may assist in treatment planning. Several histologic parameters guide us determination of the aggressive nature of the tumour. The aim of this Text book collating world epidemiological evidence is to stimulate research t and to highlight appropriate strategies to reduce the oral cancer burden worldwide. Recent decades have seen tremendous advances in our understanding of the etiology, biology, and molecular basis of oral cancer, as well as important clinical advances in the diagnosis and management of this disease.