Evidence based periodontics has made us understand that most of the patients having various dental or medical treatment requirements require multidisciplinary approach rather than personalised periodontal approach. Periodontal disease may be evident in the periodontal tissue but its onset and progression could be affected by systemic condition also. The intercommunication and liaison between periodontics and endodontics, fixed prosthodontics, implant dentistry, Orthodontics, oral pathology, Aesthetic dentistry, oral & maxillofacial surgery, Paediatric dentistry, gerodontology, radiology, special needs dentistry and general medicine needs to be discussed. Increasing life expectancy, higher quality of Biomaterials used in dentistry and rapid evolution of clinical procedures has led to more demanding patient requests & more complicated treatment choices. It requires holistic management. In this chapter we have made a conscious effort to touch upon various fields of medical science and its relation to periodontics, by which we wish to create a healthy referral protocol, benefiting the general population.