Exploring the Scientific Research (Volume - 3)

The rapid spread of Multi-Drug Resistant (MDR) bacteria poses a critical threat to global health, making the discovery of novel antibacterial agents essential. This book explores the potential of Mur ligases, a family of bacterial enzymes crucial for peptidoglycan biosynthesis, as promising drug targets. Focus is placed on Bordetella bronchialis, a respiratory pathogen with a significant role in human infections. Through in silico approaches, the book offers a comprehensive structural characterization of the MurE ligase in B. bronchialis, which is highly selective for both Gram-positive and Gram-negative bacteria. This research opens avenues for the development of new antibacterial therapies.